Biosketch

BIOGRAPHICAL SKETCH
NAME

Horsager, Alan

CURRENT POSITIONS

Chief Executive Officer (Episona, Inc.)

Research Assistant Professor (Visiting, USC)

eRA COMMONS USERNAME

horsagerPI

EDUCATION / TRAINING
INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
University of Washington, Seattle, WA B.A. 1997 Psychology
University of Southern California, Los Angeles, CA Ph.D. 2009 Neuroscience
  1. PERSONAL STATEMENT

The goal of the proposed research is to develop an innovative diagnostic tool to predict the likelihood of a successful pregnancy based on the epigenetic profile of sperm.  Although this is a scientific departure from my previous work in vision neuroscience, I do have direct experience and expertise in translating academic scientific discoveries into commercially relevant products.  Additionally, I have brought together a team of experts in reproductive medicine (Douglas Carrell), men’s health (Paul Turek), and epigenetics (Andrew Smith) that have established track records in their respective fields.  Together, our team has the commercial and scientific expertise to successfully complete the aims of this proposal.  Most recently, I was a Founder and Chief Science Officer of Eos Neuroscience, a company that continues to engineer optogenetic gene therapies for blindness and chronic pain.  Prior to Eos and while at the University of Southern California, I worked closely with Second Sight Medical Products to produce the first ever treatment of neurological blindness, a medical device that is now approved by the FDA for the treatment of retinitis pigmentosa.  Before joining USC, I was a Project Manager and Researcher at VivoMetrics, a medical device startup that developed a wearable ambulatory monitoring system that continuously collected cardiopulmonary data.  Additionally, I have numerous scientific publications and issued patents, and have received several career awards from the Coulter Foundation, Baxter Foundation, and the Burroughs Wellcome Fund (CASI award).  In summary, I have a demonstrated scientific and commercialization record that has prepared me to successfully lead the proposed project.

  1. POSITIONS & HONORS

Positions and Employment

2000 – 2003              Clinical Project Manager/Research Coordinator, VivoMetrics, Inc., Ventura, CA

2003 – 2004              Clinical Research Coordinator, California Clinical Trials Medical Group, Culver City, CA

2004 – 2009              Research Assistant (Ph.D. Student), University of Southern California, Los Angeles, CA

2007 – 2013              Chief Science Officer & Co-Founder, Eos Neuroscience, Inc., Los Angeles, CA

2009 – 2013              Instructor, Department of Ophthalmology, University of Southern California, Los Angeles, CA

2013 –                           Research Assistant Professor (Visiting), Department of Ophthalmology, USC, Los Angeles, CA

2013 –                           President, CEO, & Co-Founder, Episona, Inc., Los Angeles, CA

 

Selected Other Experience and Professional Memberships

2005 –                     Member, Society for Neuroscience (SfN)

2006 – 2012        Member, Association for Research in Vision and Ophthalmology (ARVO)

2009 –                 Inventor, Intellectual Ventures (Inventor Network), Seattle, WA

2010 –                     Member, American Society of Cell & Gene Therapy (ASGCT)

2012                    X Prize Foundation, Visioneering Workshop

2013 –                 Member, American Society for Reproductive Medicine (ASRM)

 

Selected Issued Patents

Matthew J. McMahon, Arup Roy, Scott Greenwald, Ione Fine, Alan Horsager, Avraham I. Caspi, Kelly H. McClure, Robert J. Greenberg. 2012. Visual Prosthesis Fitting. U.S. Patents 7,908,011 and 8,271,091.

Rongqing Dai, Ione Fine, Robert Greenberg, Amy Hines, Alan Horsager, Mark Humayun, Matthew McMahon, Arup Roy, James Weiland, Sumit Yadav, Dao Zhou. 2011. Fitting a Neural Prosthesis Using Electrode Impedance and Height.  U.S. Patents 8,180,454 and 8,190,267.

Alan Horsager, Scott H. Greenwald, Mark S. Humayun, Matthew J. McMahon, Ione Fine, Robert J. Greenberg, Geoffrey M. Boynton. 2013. Apparatus and method for electrical stimulation of human neurons. U.S. Patents 8,244,364, 8,311,634, and 8,457,754.

Alan Horsager, Robert J. Greenberg, Matthew J. McMahon. Visual Prosthesis for Control of Spatiotemporal Interactions. US Patent 8,626,306.

Alan Horsager, Geoffrey M. Boynton, Ione Fine, Robert J. Greenberg. Multi-Electrode Integration in a Visual Prosthesis. US Patent 8,620,442.

Alan Horsager, William Hauswirth, Jianwen Liu, Benjamin Matteo, Ed Boyden. Vectors for delivery of light sensitive proteins and methods of use. US Patent Application 12/933,092. Filed May 2009. Issued in UK: GB2472964.

Selected Pending Patents

Alan Horsager, Kenneth Greenberg, Benjamin Matteo, Edward Boyden, Douglas G. Ririe, James C. Eisenach, Christian Wentz. Methods and compositions for decreasing chronic pain. US Patent Application 13/637,977. Filed Apr 2011.

Alan Horsager, Benjamin C. Matteo, Andrew Smith. Modulation of Neural Pathways. US Patent Application 13/879,004. Filed Oct 2011.

Robert J. Greenberg, Alan Horsager, Mark S. Humayun, Kelly McClure, Matthew J. McMahon, Peter Meilstrup, Neha Parikh, Arup Roy, James D. Weiland, Chunhong Zhou. Saliency-based apparatus and methods for visual prostheses. US Patent Application 12/043,830. Filed Mar 2008.

Robert J. Greenberg, Ione Fine, Arup Roy, Matthew J. McMahon, Mark S. Humayun, James D. Weiland, Alan Horsager, Dao Zhou, Amy Hines, Sumit Yadav, Rongqing Dai. Locating a Neural Prosthesis using Impedance and Electrode Height. US Patent Application 13/452,300. Filed Apr 2012.

Honors & Awards

2005 – 2006        Professional Development Award, USC

2007                        Association for Research in Vision and Ophthalmology (ARVO) travel grant

2008                        TATRC Medical Innovation Award

2009                        Coulter Foundation Early Career Award in Translational Research

2010                        Baxter Foundation Junior Faculty Award

2011                        Burroughs Wellcome Fund, Careers at the Scientific Interface Award

 

Selected Invited Talks

2005                        Perceptual effect of retinal electrical stimulation using pulse trains, Society for Neuroscience, Washington, D.C.

2006                        A model describing human retinal electrical stimulation using pulse trains, The Eye and the Chip, Detroit, MI.

2007                        A model of temporal integration during electrical stimulation of the human retina, Computational Systems Neuroscience (CoSyNe), Salt Lake City, UT.

2007                        Evidence for synchrony using direct electrical stimulation of the human retina, Vision Sciences Society, Sarasota, FL.

2008                        Spatiotemporal interactions during multi-electrode stimulation in retinal prosthesis patients, The Eye and the Chip, Detroit, MI.

2009                        Prosthetic Vision: Restoring Sensation & Perception Using Electrical and Optogenetic Methods in the Absence of Photoreceptors. Stanford University, Palo Alto, CA.

2009                        Visual perception during retinal electrical stimulation, Pan-American Study Institute, Buenos Aires, Argentina.

2010                        Restoring Visual Function in Blind Mice Using Virally-Delivered Channelrhodopsin. International Conference on Retinal Proteins, Santa Cruz, CA.

2011           Channelrhodopsin-2 for Treating Vision Loss in Human Patients, Boston University, Future of Light Symposium, Boston, MA.

2011                    Blindness + Sight, TEDxUSC, Los Angeles, CA.

2011               Virally-Delivered  Channelrhodopsin-2  for  Restoring  Visual  Function.  Stanford  University,  Stanford  Photonics Research Center, Palo Alto, CA.

2011              Virally-Delivered Channelrhodopsin-2 for Restoring Visual Function.  Bay Area Vision Research Day, UC Berkeley, Berkeley, CA.

2012                   Genetically  Targeted  Neural  Modulation  Restores  Functional  Vision  in  Mouse  Models  of  Blindness.  ARVO Drug and Gene Delivery to the Back of the Eye, Denver, CO.

2012                   An  Optogenetic  Approach  to  Establishing  Light Sensitivity in the Inner Retina, International Society of Eye Research, Berlin, Germany.

2012                  Virally-Delivered   Channelrhodopsin-2  for  Restoring  Visual  Function.   Federacao  de  Sociedades   de Biologia Experimental, Sao Paulo, Brasil.

2012                An Optogenetic Approach to Establishing Light Sensitivity in the Inner Retina. Regenerative Medicine in Glaucoma, Vanderbilt University, Nashville, TN.

2013                        An Optogenetic Approach to Establishing Light Sensitivity in the Inner Retina.  The International Symposium on Ocular Pharmacology and Therapeutics, Paris, France.      

  1. PUBLICATIONS & BOOK CHAPTERS

Peer-Reviewed Publications

  1. De Balthasar, C., Patel, S., Roy, A., Freda, R., Greewald, S.H., Horsager, A., Mahadevappa, M., Yanai, D., McMahon, M.J., Humayun, M.S., Greenberg, R.J., Weiland, J.D., Fine, I. Factors affecting perceptual thresholds in epiretinal prostheses. Vis. Ophth. Sci. 2008 Jun;49(6):2303-14.
  2. Horsager, A., Greenwald, S.H., Weiland, J.D., Humayun, M.S., Greenberg, R.J., McMahon, M.J., Boynton, G.M., Fine, I. Predicting visual sensitivity in retinal prosthesis patients. Inv. Vis. Ophth. Sci. 2009 Apr;50(4):1483-91.
  3. Greenwald, S.H., Horsager, A., Humayun, M.S., Greenberg, R.J., McMahon, M.J., Fine, I. Brightness as a function of current amplitude in human retinal stimulation. Inv. Vis. Ophth. Sci. 2009 Nov;50(11):5017-25.
  4. Horsager, A., Greenberg, R.J., Fine, I. Spatiotemporal interactions in retinal prosthesis patients. Vis. Ophth. Sci. 2010 Feb;51(2):1223-33.
  5. Horsager, A., Boynton, G.M., Greenberg, R.J., Fine, I. Temporal interactions during paired-electrode stimulation in retinal prosthesis patients. Inv. Vis. Ophth. Sci. 2011 Feb 1;52(1):549-57.
  6. Doroudchi, M.M., Greenberg, K.P., Liu, J.W., Silka, K.A., Boyden, E.S., Lockridge, J.A., Arman, A.C., Janani, R., Boye, S.E., Boye, S.L., Gordon, G.M., Matteo, B.C., Sampath, A.P., Hauswirth, W.W., Horsager, A. Virally-Delivered, Genetically-Targeted Expression of Channelrhodopsin-2 Restores Visual Function in Multiple Mouse Models of Blindness. Mol Ther. 2011 Jul;19(7):1220-9.
  7. Nanduri, D., Fine, I., Horsager, A., Boynton, G.M., Humayun, M.S., Greenberg, R.J., Weiland, J.D. Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation.  Invest Ophthalm Vis Sci. 2011 Nov. 22.
  8. Doroudchi, M.M., Greenberg, K.P., Zorzos, A.N., Hauswirth, W.W., Fonstad, C.G., Horsager, A., Boyden, E.S. Towards Optogenetic Sensory Replacement. Conf Proc IEEE Eng med Biol Soc. 2011 Aug;2011:3139-41.
  9. Row-Rendleman, C.L., Kompella, U.B., Durazo, S.A., Rittenhouse, K.D., Di Polo, A., Weiner, A., Grossniklaus, H.E., Naash, M., Lewin, A., Horsager, A., Edelhauser, H.F. Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside. Invest Ophthalm Vis Sci. 2014 Apr 28;55(4):2714-30.
  10. Uren, P., Lee, J., Doroudchi, M.M., Smith, A.D., Horsager, A. A profile of transcriptomic changes in the rd10 mouse model of retinal degeneration. Mol Vision. (In Press).
  11. Nanduri, D., Fine, I., Greenberg, R.J., Horsager, A., Boynton, G.M., Weiland, J.D. The visual experience of epiretinal prosthesis users. (In Preparation).

Book Chapters

  1. Chader, G.J., Horsager, A., Weiland, J., Humayun, M.S. “Injury & Repair: Prostheses.” In Dartt, D.A., Besharse, J.C., Dana, R. (Eds.), Encyclopedia of the Eye (Volume 2, pp. 408-413). Oxford, Academic Press.
  2. Horsager, A. and Fine, I. “The perceptual effects of chronic retinal stimulation.” In Dagnelie, G. (Eds.), Visual Prosthetics: Physiology, Bioengineering, and Rehabilitation. Springer; 2011. pp. 271-300.

 

Selected Recent Abstracts

  1. Jian Wen Liu, Alan Horsager, Ding, S. Mani, V.A. Chiodo, Ed S. Boyden, William W. Hauswirth (2009). “AAV-Mediated ON Bipolar Cell Targeting in the rd1 Mouse Lacking Photoreceptors”. Association for Research in Vision and Ophthalmology 3011/A5. [Poster]
  2. Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2009). “Restoring Visual Function in Adult rd1 Mice Using Virally-Delivered Channelrhodopsin”. Association for Research in Vision and Ophthalmology 3898. [Talk]
  3. Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2009). “Restoring Visual Function in Adult rd1 Mice Using Virally-Delivered Channelrhodopsin”. Society for Neuroscience. [Talk]
  4. Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2010). “Restoring Visual Function in Adult rd1 Mice Using Virally-Delivered Channelrhodopsin”. American Society for Gene and Cell Therapy. [Talk]
  5. Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2010). “Circuit-specific expression of channelrhodopsin restores visual function in 4 different mouse models of blindness”. Cold Spring Harbor Laboratories, Neural Circuits Conference. [poster]
  6. Devyani Nanduri, Ione Fine, Robert J. Greenberg, Alan Horsager, Geoffrey M. Boynton, James D. Weiland. “Predicting the percepts of electrical stimulation in retinal prosthesis subjects”. Computational Systems Neuroscience. 261. [poster]
  7. RESEARCH SUPPORT

Burroughs Wellcome Fund Careers at the Scientific Interface            (2011 – 2016)

Using Genetically-Targeted Neural Modulation to Examine Retinal Circuits and Restore Vision

Role: PI  Amount: $500,000

R43 EY022836-01 (NEI Phase I SBIR)  (2012 – 2013)

Optimization of an Optogenetic-Based Vision Therapy for Retinitis Pigmentosa

Role: PI  Amount:  $296,422

R43 NS073285-01 (NINDS Phase I SBIR)  (2011 – 2012)

Development of an Optical Silencer-Based Genetic Therapy for Neuropathic Pain

Role:  PI (co-PI with Drs. Greenberg and Ririe)  Amount:  $394,000

Therapeutic Discovery Grant (Internal Revenue Service)  (2011)

Development of EOS-013, a Therapy to Restore Vision to Blind RP and AMD Patients

Role:  PI  Amount:  $244,479

Coulter Foundation Early Career Award in Translational Research  (2009 – 2011)

Optical Neuromodulation: Translational Application to Blindness

Role:  PI (co-PI with Dr. Ed Boyden)  Amount:  $260,000

Baxter Foundation Junior Faculty Award                    (2010 – 2011)

An Optogenetic Approach to Treating Blindness

Role: PI  Amount:  $100,000

R43 EY019201-01A1S1 (NEI Phase I SBIR)  (2009 – 2011)

Establishing Channelrhodopsin as a Tool to Restore Visual Function

Role:  PI  (co-PI with Dr. William Hauswirth)  Amount:   $388,300