Chief Executive Officer (Episona, Inc.)
Research Assistant Professor (Visiting, USC)
|eRA COMMONS USERNAME
|EDUCATION / TRAINING|
|INSTITUTION AND LOCATION||DEGREE||YEAR(s)||FIELD OF STUDY|
|University of Washington, Seattle, WA||B.A.||1997||Psychology|
|University of Southern California, Los Angeles, CA||Ph.D.||2009||Neuroscience|
- PERSONAL STATEMENT
The goal of the proposed research is to develop an innovative diagnostic tool to predict the likelihood of a successful pregnancy based on the epigenetic profile of sperm. Although this is a scientific departure from my previous work in vision neuroscience, I do have direct experience and expertise in translating academic scientific discoveries into commercially relevant products. Additionally, I have brought together a team of experts in reproductive medicine (Douglas Carrell), men’s health (Paul Turek), and epigenetics (Andrew Smith) that have established track records in their respective fields. Together, our team has the commercial and scientific expertise to successfully complete the aims of this proposal. Most recently, I was a Founder and Chief Science Officer of Eos Neuroscience, a company that continues to engineer optogenetic gene therapies for blindness and chronic pain. Prior to Eos and while at the University of Southern California, I worked closely with Second Sight Medical Products to produce the first ever treatment of neurological blindness, a medical device that is now approved by the FDA for the treatment of retinitis pigmentosa. Before joining USC, I was a Project Manager and Researcher at VivoMetrics, a medical device startup that developed a wearable ambulatory monitoring system that continuously collected cardiopulmonary data. Additionally, I have numerous scientific publications and issued patents, and have received several career awards from the Coulter Foundation, Baxter Foundation, and the Burroughs Wellcome Fund (CASI award). In summary, I have a demonstrated scientific and commercialization record that has prepared me to successfully lead the proposed project.
- POSITIONS & HONORS
Positions and Employment
2000 – 2003 Clinical Project Manager/Research Coordinator, VivoMetrics, Inc., Ventura, CA
2003 – 2004 Clinical Research Coordinator, California Clinical Trials Medical Group, Culver City, CA
2004 – 2009 Research Assistant (Ph.D. Student), University of Southern California, Los Angeles, CA
2007 – 2013 Chief Science Officer & Co-Founder, Eos Neuroscience, Inc., Los Angeles, CA
2009 – 2013 Instructor, Department of Ophthalmology, University of Southern California, Los Angeles, CA
2013 – Research Assistant Professor (Visiting), Department of Ophthalmology, USC, Los Angeles, CA
2013 – President, CEO, & Co-Founder, Episona, Inc., Los Angeles, CA
Selected Other Experience and Professional Memberships
2005 – Member, Society for Neuroscience (SfN)
2006 – 2012 Member, Association for Research in Vision and Ophthalmology (ARVO)
2009 – Inventor, Intellectual Ventures (Inventor Network), Seattle, WA
2010 – Member, American Society of Cell & Gene Therapy (ASGCT)
2012 X Prize Foundation, Visioneering Workshop
2013 – Member, American Society for Reproductive Medicine (ASRM)
Selected Issued Patents
Matthew J. McMahon, Arup Roy, Scott Greenwald, Ione Fine, Alan Horsager, Avraham I. Caspi, Kelly H. McClure, Robert J. Greenberg. 2012. Visual Prosthesis Fitting. U.S. Patents 7,908,011 and 8,271,091.
Rongqing Dai, Ione Fine, Robert Greenberg, Amy Hines, Alan Horsager, Mark Humayun, Matthew McMahon, Arup Roy, James Weiland, Sumit Yadav, Dao Zhou. 2011. Fitting a Neural Prosthesis Using Electrode Impedance and Height. U.S. Patents 8,180,454 and 8,190,267.
Alan Horsager, Scott H. Greenwald, Mark S. Humayun, Matthew J. McMahon, Ione Fine, Robert J. Greenberg, Geoffrey M. Boynton. 2013. Apparatus and method for electrical stimulation of human neurons. U.S. Patents 8,244,364, 8,311,634, and 8,457,754.
Alan Horsager, Robert J. Greenberg, Matthew J. McMahon. Visual Prosthesis for Control of Spatiotemporal Interactions. US Patent 8,626,306.
Alan Horsager, Geoffrey M. Boynton, Ione Fine, Robert J. Greenberg. Multi-Electrode Integration in a Visual Prosthesis. US Patent 8,620,442.
Alan Horsager, William Hauswirth, Jianwen Liu, Benjamin Matteo, Ed Boyden. Vectors for delivery of light sensitive proteins and methods of use. US Patent Application 12/933,092. Filed May 2009. Issued in UK: GB2472964.
Selected Pending Patents
Alan Horsager, Kenneth Greenberg, Benjamin Matteo, Edward Boyden, Douglas G. Ririe, James C. Eisenach, Christian Wentz. Methods and compositions for decreasing chronic pain. US Patent Application 13/637,977. Filed Apr 2011.
Alan Horsager, Benjamin C. Matteo, Andrew Smith. Modulation of Neural Pathways. US Patent Application 13/879,004. Filed Oct 2011.
Robert J. Greenberg, Alan Horsager, Mark S. Humayun, Kelly McClure, Matthew J. McMahon, Peter Meilstrup, Neha Parikh, Arup Roy, James D. Weiland, Chunhong Zhou. Saliency-based apparatus and methods for visual prostheses. US Patent Application 12/043,830. Filed Mar 2008.
Robert J. Greenberg, Ione Fine, Arup Roy, Matthew J. McMahon, Mark S. Humayun, James D. Weiland, Alan Horsager, Dao Zhou, Amy Hines, Sumit Yadav, Rongqing Dai. Locating a Neural Prosthesis using Impedance and Electrode Height. US Patent Application 13/452,300. Filed Apr 2012.
Honors & Awards
2005 – 2006 Professional Development Award, USC
2007 Association for Research in Vision and Ophthalmology (ARVO) travel grant
2008 TATRC Medical Innovation Award
2009 Coulter Foundation Early Career Award in Translational Research
2010 Baxter Foundation Junior Faculty Award
2011 Burroughs Wellcome Fund, Careers at the Scientific Interface Award
Selected Invited Talks
2005 Perceptual effect of retinal electrical stimulation using pulse trains, Society for Neuroscience, Washington, D.C.
2006 A model describing human retinal electrical stimulation using pulse trains, The Eye and the Chip, Detroit, MI.
2007 A model of temporal integration during electrical stimulation of the human retina, Computational Systems Neuroscience (CoSyNe), Salt Lake City, UT.
2007 Evidence for synchrony using direct electrical stimulation of the human retina, Vision Sciences Society, Sarasota, FL.
2008 Spatiotemporal interactions during multi-electrode stimulation in retinal prosthesis patients, The Eye and the Chip, Detroit, MI.
2009 Prosthetic Vision: Restoring Sensation & Perception Using Electrical and Optogenetic Methods in the Absence of Photoreceptors. Stanford University, Palo Alto, CA.
2009 Visual perception during retinal electrical stimulation, Pan-American Study Institute, Buenos Aires, Argentina.
2010 Restoring Visual Function in Blind Mice Using Virally-Delivered Channelrhodopsin. International Conference on Retinal Proteins, Santa Cruz, CA.
2011 Channelrhodopsin-2 for Treating Vision Loss in Human Patients, Boston University, Future of Light Symposium, Boston, MA.
2011 Blindness + Sight, TEDxUSC, Los Angeles, CA.
2011 Virally-Delivered Channelrhodopsin-2 for Restoring Visual Function. Stanford University, Stanford Photonics Research Center, Palo Alto, CA.
2011 Virally-Delivered Channelrhodopsin-2 for Restoring Visual Function. Bay Area Vision Research Day, UC Berkeley, Berkeley, CA.
2012 Genetically Targeted Neural Modulation Restores Functional Vision in Mouse Models of Blindness. ARVO Drug and Gene Delivery to the Back of the Eye, Denver, CO.
2012 An Optogenetic Approach to Establishing Light Sensitivity in the Inner Retina, International Society of Eye Research, Berlin, Germany.
2012 Virally-Delivered Channelrhodopsin-2 for Restoring Visual Function. Federacao de Sociedades de Biologia Experimental, Sao Paulo, Brasil.
2012 An Optogenetic Approach to Establishing Light Sensitivity in the Inner Retina. Regenerative Medicine in Glaucoma, Vanderbilt University, Nashville, TN.
2013 An Optogenetic Approach to Establishing Light Sensitivity in the Inner Retina. The International Symposium on Ocular Pharmacology and Therapeutics, Paris, France.
- PUBLICATIONS & BOOK CHAPTERS
- De Balthasar, C., Patel, S., Roy, A., Freda, R., Greewald, S.H., Horsager, A., Mahadevappa, M., Yanai, D., McMahon, M.J., Humayun, M.S., Greenberg, R.J., Weiland, J.D., Fine, I. Factors affecting perceptual thresholds in epiretinal prostheses. Vis. Ophth. Sci. 2008 Jun;49(6):2303-14.
- Horsager, A., Greenwald, S.H., Weiland, J.D., Humayun, M.S., Greenberg, R.J., McMahon, M.J., Boynton, G.M., Fine, I. Predicting visual sensitivity in retinal prosthesis patients. Inv. Vis. Ophth. Sci. 2009 Apr;50(4):1483-91.
- Greenwald, S.H., Horsager, A., Humayun, M.S., Greenberg, R.J., McMahon, M.J., Fine, I. Brightness as a function of current amplitude in human retinal stimulation. Inv. Vis. Ophth. Sci. 2009 Nov;50(11):5017-25.
- Horsager, A., Greenberg, R.J., Fine, I. Spatiotemporal interactions in retinal prosthesis patients. Vis. Ophth. Sci. 2010 Feb;51(2):1223-33.
- Horsager, A., Boynton, G.M., Greenberg, R.J., Fine, I. Temporal interactions during paired-electrode stimulation in retinal prosthesis patients. Inv. Vis. Ophth. Sci. 2011 Feb 1;52(1):549-57.
- Doroudchi, M.M., Greenberg, K.P., Liu, J.W., Silka, K.A., Boyden, E.S., Lockridge, J.A., Arman, A.C., Janani, R., Boye, S.E., Boye, S.L., Gordon, G.M., Matteo, B.C., Sampath, A.P., Hauswirth, W.W., Horsager, A. Virally-Delivered, Genetically-Targeted Expression of Channelrhodopsin-2 Restores Visual Function in Multiple Mouse Models of Blindness. Mol Ther. 2011 Jul;19(7):1220-9.
- Nanduri, D., Fine, I., Horsager, A., Boynton, G.M., Humayun, M.S., Greenberg, R.J., Weiland, J.D. Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation. Invest Ophthalm Vis Sci. 2011 Nov. 22.
- Doroudchi, M.M., Greenberg, K.P., Zorzos, A.N., Hauswirth, W.W., Fonstad, C.G., Horsager, A., Boyden, E.S. Towards Optogenetic Sensory Replacement. Conf Proc IEEE Eng med Biol Soc. 2011 Aug;2011:3139-41.
- Row-Rendleman, C.L., Kompella, U.B., Durazo, S.A., Rittenhouse, K.D., Di Polo, A., Weiner, A., Grossniklaus, H.E., Naash, M., Lewin, A., Horsager, A., Edelhauser, H.F. Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside. Invest Ophthalm Vis Sci. 2014 Apr 28;55(4):2714-30.
- Uren, P., Lee, J., Doroudchi, M.M., Smith, A.D., Horsager, A. A profile of transcriptomic changes in the rd10 mouse model of retinal degeneration. Mol Vision. (In Press).
- Nanduri, D., Fine, I., Greenberg, R.J., Horsager, A., Boynton, G.M., Weiland, J.D. The visual experience of epiretinal prosthesis users. (In Preparation).
- Chader, G.J., Horsager, A., Weiland, J., Humayun, M.S. “Injury & Repair: Prostheses.” In Dartt, D.A., Besharse, J.C., Dana, R. (Eds.), Encyclopedia of the Eye (Volume 2, pp. 408-413). Oxford, Academic Press.
- Horsager, A. and Fine, I. “The perceptual effects of chronic retinal stimulation.” In Dagnelie, G. (Eds.), Visual Prosthetics: Physiology, Bioengineering, and Rehabilitation. Springer; 2011. pp. 271-300.
Selected Recent Abstracts
- Jian Wen Liu, Alan Horsager, Ding, S. Mani, V.A. Chiodo, Ed S. Boyden, William W. Hauswirth (2009). “AAV-Mediated ON Bipolar Cell Targeting in the rd1 Mouse Lacking Photoreceptors”. Association for Research in Vision and Ophthalmology 3011/A5. [Poster]
- Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2009). “Restoring Visual Function in Adult rd1 Mice Using Virally-Delivered Channelrhodopsin”. Association for Research in Vision and Ophthalmology 3898. [Talk]
- Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2009). “Restoring Visual Function in Adult rd1 Mice Using Virally-Delivered Channelrhodopsin”. Society for Neuroscience. [Talk]
- Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2010). “Restoring Visual Function in Adult rd1 Mice Using Virally-Delivered Channelrhodopsin”. American Society for Gene and Cell Therapy. [Talk]
- Alan Horsager, Jian Wen Liu, Ed S. Boyden, A. Cyrus Arman, Ben C. Matteo, A.P. Sampath, William W. Hauswirth (2010). “Circuit-specific expression of channelrhodopsin restores visual function in 4 different mouse models of blindness”. Cold Spring Harbor Laboratories, Neural Circuits Conference. [poster]
- Devyani Nanduri, Ione Fine, Robert J. Greenberg, Alan Horsager, Geoffrey M. Boynton, James D. Weiland. “Predicting the percepts of electrical stimulation in retinal prosthesis subjects”. Computational Systems Neuroscience. 261. [poster]
- RESEARCH SUPPORT
Burroughs Wellcome Fund Careers at the Scientific Interface (2011 – 2016)
Using Genetically-Targeted Neural Modulation to Examine Retinal Circuits and Restore Vision
Role: PI Amount: $500,000
R43 EY022836-01 (NEI Phase I SBIR) (2012 – 2013)
Optimization of an Optogenetic-Based Vision Therapy for Retinitis Pigmentosa
Role: PI Amount: $296,422
R43 NS073285-01 (NINDS Phase I SBIR) (2011 – 2012)
Development of an Optical Silencer-Based Genetic Therapy for Neuropathic Pain
Role: PI (co-PI with Drs. Greenberg and Ririe) Amount: $394,000
Therapeutic Discovery Grant (Internal Revenue Service) (2011)
Development of EOS-013, a Therapy to Restore Vision to Blind RP and AMD Patients
Role: PI Amount: $244,479
Coulter Foundation Early Career Award in Translational Research (2009 – 2011)
Optical Neuromodulation: Translational Application to Blindness
Role: PI (co-PI with Dr. Ed Boyden) Amount: $260,000
Baxter Foundation Junior Faculty Award (2010 – 2011)
An Optogenetic Approach to Treating Blindness
Role: PI Amount: $100,000
R43 EY019201-01A1S1 (NEI Phase I SBIR) (2009 – 2011)
Establishing Channelrhodopsin as a Tool to Restore Visual Function
Role: PI (co-PI with Dr. William Hauswirth) Amount: $388,300